NUSADAILY.COM – LONDON – British scientists on Monday launched tests by infecting participants who have contracted COVID-19 with coronavirus again. To check the immune response and see if people can be re-infected.
In February, the UK became the first country in the world to give the green light to human “challenge trials”, namely volunteers deliberately being infected with COVID-19 to advance research on diseases caused by coronavirus.
The study, which was launched on Monday, was different from the one announced on Feb.
This study seeks to re-infect people who previously suffered from COVID-19. In order to deepen the understanding of human immunity to coronavirus.
In previous studies, such trials were conducted by infecting people for the first time.
“The information from this trial will allow us to design better vaccines and treatments. And also to understand if people are protected after contracting COVID, and for how long,”. Said Helen McShane, Oxford University vaccination expert and chief researcher in the study.
Scientists have been using trial challenges against humans for decades to learn more about diseases such as malaria, flu, typhus and cholera. And to develop treatments and vaccines to fight these diseases.
The first phase of the trial will attempt to establish the lowest dose of coronavirus. That is necessary in order to start replicating at about 50 percent.
The second phase of the trial, which began in the summer, will be conducted by infecting volunteers different from the standard dose.
In the first phase, up to 64 participants in healthy condition and aged 18-30 years — who had previously been infected with coronavirus at least three months ago — will be re-transmitted with the original type of SARS-CoV-2 virus.
The participants will then be quarantined for at least 17 days and monitored, and anyone experiencing symptoms will be given regeneron monoclonal antibody treatment. (int2)